Genetic Testing

Inherited chromosome abnormalities may contribute to low or no sperm counts. In these circumstances, genetic screening from a blood sample (karyotype, Y-deletion or cystic fibrosis screening) may be offered. Genetic damage to sperm is not always inherited and can occur at any time in a man's life. To screen for non-inherited genetic defects the sperm sample needs to be analysed directly for abnormal chrmosome numbers (aneuploidy) of for damage to the DNA (DNA fragmentation). Genetic defects are not always associated with poor sperm parameters. Because genetically abnormal sperm result in abnormal embryos, genetic testing may also be recommended for couples with recurrent miscarriage or years of unexplained infertility. Unfortunately, inherited abnormalities are untreatable, but depending on your situation, pre-implantation genetic screening may be offered as a fertility treatment option.

Recent studies suggest that antioxidants may be beneficial in improving levels of DNA fragmentation, but more studies are needed.

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