Metformin, Clomid, and Other Medications: Fertility Treatment Options for PCOS

An important update: On 12 May 2026, an international consensus published in The Lancet renamed Polycystic Ovary Syndrome (PCOS) to Polyendocrine Metabolic Ovarian Syndrome (PMOS). The new name reflects what we now understand about the condition's wider hormonal effects. Both names will be used during the transition to the 2028 ICD update. Read our explainer on what the rename means for your hormones and fertility.

If you're dealing with Polycystic Ovary Syndrome (PCOS), now PMOS, and you're considering getting pregnant, you may be wondering what your options are for increasing your chances of success.

Let's explore the different medications often recommended for improving fertility in PMOS (PCOS), as well as lifestyle changes that can further enhance your chances.

Why Does PCOS Affect Fertility?

PMOS (PCOS) is one of the leading causes of infertility among women. The hormonal imbalances, including elevated levels of male hormones and irregularities in oestrogen and progesterone, often lead to ovulatory issues. This can make getting pregnant with PCOS challenging.

Commonly Prescribed Medications

Metformin

Commonly used to treat insulin resistance, Metformin can also help regulate ovulation and thereby improve fertility in women with PMOS (PCOS). It addresses insulin resistance, a key factor in PCOS side effects that can contribute to infertility.

Clomid

Clomiphene citrate, better known as Clomid, is often the first medication doctors prescribe for PMOS (PCOS)-related fertility issues. It works by stimulating the ovaries to release eggs.

Lifestyle Changes to Enhance Success

Diet

A balanced diet rich in fruits, vegetables, lean proteins, and whole grains can help regulate insulin levels and improve the symptoms of PMOS (PCOS). Specifically, focusing on low-glycemic foods can mitigate insulin resistance, further aiding fertility efforts.

Exercise

Regular physical activity can help manage insulin resistance and other symptoms of PCOS. A combination of cardio and strength training is highly beneficial for improving fertility outcomes.

Supplements for Enhanced Fertility

Inositol

Particularly myo-inositol is recommended for its role in improving ovary function and fertility among women with PMOS (PCOS).

Omega-3 Fatty Acids

These essential fatty acids are known for reducing inflammation and may help improve hormonal balance in PMOS (PCOS) patients.

Vitamin D

Vitamin D deficiency is commonly found in women with PMOS (PCOS) and may negatively impact fertility. Supplementing with Vitamin D can improve metabolic parameters.

Enhanced Fertility After 30

While fertility generally declines with age, by combining medical treatment with lifestyle changes, your chances of getting pregnant with PMOS (PCOS) after 30 can be significantly enhanced.

It's essential to consult a healthcare provider for a tailored treatment plan that addresses your individual needs, especially if you're dealing with the complexities of PMOS (PCOS) and fertility.

PMOS (PCOS) can present numerous challenges to fertility, but with the right treatment and lifestyle changes, many successfully conceive. If you're considering getting pregnant and have PMOS (PCOS), a combination of medications, diet, exercise, and supplements can significantly improve your chances.