Article

CoQ10 and Fertility: What the Research Says About Egg Quality, Sperm Health and IVF

Posted on July 23, 2026

How CoQ10 may support egg quality, sperm health and IVF preparation, with a balanced look at the research and guidance on when to consider supplementation.

Medical disclaimer: this article is for general information and does not replace personal advice from a GP, fertility clinic or qualified healthcare professional.

Quick answer: how does CoQ10 relate to fertility?

CoQ10 is often discussed in fertility because it supports mitochondrial energy production and antioxidant protection, both of which are relevant to egg and sperm health. Eggs rely on mitochondrial energy during maturation, while sperm need energy for motility, so CoQ10 is commonly considered during the preconception window, especially by couples preparing for IVF, women over 35, people concerned about egg quality, and men wanting to support sperm health.

Research on CoQ10 and fertility is promising but not conclusive. Some studies point to improved ovarian response or clinical pregnancy rate, while evidence for live birth is still developing. Zita West uses Kaneka Ubiquinol, the active ubiquinol form of CoQ10, in its fertility-focused supplement range because it is highly bioavailable and well suited to preconception supplementation. CoQ10 should be viewed as supportive nutrition, not a guaranteed fertility treatment or a replacement for medical fertility care.

In this CoQ10 fertility guide

Use this guide as your starting point for understanding CoQ10, fertility, egg quality, sperm health, IVF preparation, dosage, timing and Kaneka Ubiquinol.

CoQ10 is a nutrient involved in mitochondrial energy production and antioxidant protection. Because eggs and sperm rely on healthy mitochondrial function, CoQ10 is often studied in relation to egg quality, sperm motility and IVF preparation. Current research suggests potential fertility benefits, particularly for semen parameters and some assisted reproduction outcomes, although CoQ10 should be seen as supportive nutrition rather than a guaranteed fertility treatment.

What is CoQ10?

Coenzyme Q10 (CoQ10) is a vitamin-like compound that the body produces naturally. It plays a central role in cellular energy production, helping mitochondria generate ATP, the energy currency that every cell relies on to function. CoQ10 also acts as an antioxidant, helping to protect cells from oxidative stress.

Natural CoQ10 levels tend to decline with age, which is one reason the nutrient is often discussed in fertility and IVF contexts. CoQ10 exists in two main forms: ubiquinone, the oxidised form, and ubiquinol, the reduced and directly usable antioxidant form.

Ubiquinol is the active, reduced form of CoQ10 — it already functions as an antioxidant without needing to be converted first. Ubiquinone is the oxidised form, and the body converts it into ubiquinol as needed. This conversion step is one reason ubiquinol is often chosen in fertility supplementation: it is already in the form the body uses.

For a fuller explanation of how the two forms differ and why this matters for egg and sperm health, see our guide to ubiquinol vs ubiquinone for fertility.

Zita West Kaneka Ubiquinol

Our CoQ10 supplement uses Kaneka Ubiquinol, a highly bioavailable active form, formulated for women and men preparing for conception.

Shop Kaneka Ubiquinol

Why CoQ10 is discussed in fertility

Eggs and sperm are among the most energy demanding cells in the body. Mitochondria help power egg maturation, fertilisation and early embryo development, while sperm rely on mitochondrial energy to swim effectively. Oxidative stress, meanwhile, can affect egg quality, sperm motility and the integrity of sperm DNA.

Because CoQ10 supports both mitochondrial function and antioxidant protection, it has become a widely studied nutrient in reproductive health. A review of CoQ10 and human oocytes notes that optimal mitochondrial function and ATP levels matter for oocyte competence, and that CoQ10 may support reproductive performance through its role in ATP synthesis and protection against oxidative damage.^[1]

Who may consider CoQ10 during the preconception window?

CoQ10 is discussed across a range of preconception circumstances rather than one specific case. People who commonly consider it during the preconception window include:

Women over 35 preparing for conception
Women preparing for IVF or ICSI
Women concerned about egg quality or ovarian response
Men wanting to support sperm motility, concentration or morphology
Couples preparing for conception together
People advised by a fertility clinic to review mitochondrial or antioxidant support
Anyone unsure about supplements who would benefit from personalised guidance

If you are unsure whether CoQ10 is appropriate for your circumstances, you can book a free product consultation with the Zita West team.

Can CoQ10 support egg quality?

Egg quality is closely linked to mitochondrial function, which is why CoQ10 has attracted attention for women preparing for conception or assisted reproduction. CoQ10 supports mitochondrial energy production and antioxidant protection — both relevant to how an egg matures. It is commonly discussed for women over 35, for diminished ovarian reserve, and for IVF preparation. The evidence is promising, particularly around ovarian response and clinical pregnancy rate, but it is not conclusive for live birth outcomes.

Woman relaxing quietly at home during her preconception journey, taking time to care for herself while supporting egg quality

A systematic review and meta-analysis looking at women undergoing assisted reproductive technology found that CoQ10 supplementation may increase clinical pregnancy rate compared with placebo or no treatment, though it did not show a clear effect on live birth rate or miscarriage rate.^[2] A separate 2024 systematic review and meta-analysis focused on women with diminished ovarian reserve undergoing IVF or ICSI reported that CoQ10 pretreatment was associated with improved clinical pregnancy rate and other IVF related outcomes, including the number of oocytes retrieved and optimal embryos formed.^[4]

CoQ10 is often discussed in relation to egg quality because eggs rely heavily on mitochondrial energy. Research suggests it may help support the ovarian environment by contributing to mitochondrial function and antioxidant protection, though the evidence for live birth outcomes specifically is still developing.

CoQ10 for women over 35

Natural CoQ10 levels decline with age, and age-related changes in mitochondrial function are one reason CoQ10 is often discussed specifically for women over 35. This is not a guarantee that supplementation will offset age-related changes to egg quality, but it is part of why the nutrient comes up so often in this age group's preconception conversations.

For guidance on how much to take, see our CoQ10 dosage for fertility guide, and for when to start, see when to start CoQ10 before conception or IVF. Zita West's fertility-focused CoQ10 supplement, Zita West Kaneka Ubiquinol, uses the active ubiquinol form discussed throughout this guide.

CoQ10 before IVF: why timing may matter

CoQ10 is commonly considered before IVF because egg development unfolds over several months rather than days. Egg development takes place over several months, and a three-month preparation window is commonly discussed by fertility clinics, although some people may begin earlier, especially if advised to do so by their clinic.

CoQ10 is especially discussed in relation to ovarian response, age related fertility decline and diminished ovarian reserve. It should be seen as a supportive part of preconception nutrition rather than a substitute for IVF treatment or a clinic's own protocols. If you are undergoing IVF, ICSI or taking medication, always check CoQ10 supplementation with your clinic first.

For a detailed breakdown of when to start, see our guide to timing your CoQ10 supplementation for fertility.

Preparing for IVF? At Zita West, we offer fertility nutrition support and supplement guidance designed around your individual stage. Explore our IVF supplements collection, or book a free product consultation if you'd like personalised guidance before you start.

Can CoQ10 support sperm health?

Sperm motility depends on efficient energy production, so CoQ10's role in mitochondrial energy is central to why it is studied for male fertility. Research looks at its effect on sperm motility, concentration, morphology and oxidative stress. Because sperm develop over a cycle of around three months, CoQ10 is usually considered as part of a longer routine rather than a short-term fix, and is often one part of a wider male fertility supplement plan.

Man pouring a glass of water during his morning routine, part of daily habits that may support sperm health

CoQ10 has been studied for its effect on sperm concentration, motility, morphology and antioxidant status, with evidence appearing somewhat stronger for improvements in semen parameters than for pregnancy outcomes, although some research also points to possible benefits for pregnancy rates.

A systematic review found that CoQ10 supplementation, whether taken alone or combined with other antioxidants, had a beneficial effect on semen quality, particularly sperm motility, with possible improvements in antioxidant capacity and sperm chromatin integrity.^[3] More recently, a 2026 review reported meaningful improvements in sperm concentration, seminal volume and total sperm motility in men with idiopathic infertility, along with improved odds of clinical pregnancy, particularly when supplementation continued for more than three months.^[5]

For a deeper look at the research on CoQ10 and male fertility, see our guide to CoQ10 and male fertility.

Explore our male fertility support range.

Zita West Male Fertility Plus Pack

For men wanting a fuller approach alongside CoQ10, this pack combines targeted nutrients researched for sperm concentration, motility and antioxidant protection.

Shop Male Fertility Plus Pack

Ubiquinol or ubiquinone: which form of CoQ10 is used for fertility?

Ubiquinone is the oxidised form of CoQ10, while ubiquinol is the reduced form and functions directly as an antioxidant. Both are forms of the same nutrient, but ubiquinol is often chosen in fertility supplements because it does not need to be converted before it can act as an antioxidant.

Zita West uses Kaneka Ubiquinol, positioned as a highly absorbable form of CoQ10 for women and men preparing for conception, including those focused on egg quality, sperm health and IVF preparation. Read more in our guide to Kaneka Ubiquinol and fertility, or explore the Kaneka CoQ10 here.

Kaneka Ubiquinol vs standard CoQ10: what is the difference?

Kaneka Ubiquinol is a branded form of ubiquinol, the reduced and active antioxidant form of CoQ10. Standard CoQ10 supplements often use ubiquinone, which the body converts into ubiquinol. Zita West uses Kaneka Ubiquinol because fertility-focused supplementation often prioritises bioavailability, mitochondrial energy support and antioxidant protection for egg and sperm health.

	Standard CoQ10 (ubiquinone)	Ubiquinol	Kaneka Ubiquinol
What it is	The oxidised form of CoQ10	The reduced, active antioxidant form of CoQ10	A branded form of ubiquinol
How it works	The body converts it into ubiquinol before it acts as an antioxidant	Already in the active form — no conversion step needed	Functions as ubiquinol, used by Zita West in its fertility-focused CoQ10 supplement
Where it's used	Common in many general-purpose CoQ10 supplements	Often preferred where absorption and age-related conversion are a concern	A great choice for women and men preparing for conception, including egg quality, sperm health and IVF preparation

For the research behind Zita West's choice of ingredient, see Kaneka Ubiquinol and fertility research, or read more on ubiquinol vs ubiquinone for fertility. To view the product, see Zita West Kaneka Ubiquinol CoQ10.

CoQ10 dosage and timing for fertility: where to start

Many people consider CoQ10 during the three-month preconception window because egg and sperm development take place over weeks to months. Sperm production takes roughly three months, and follicle development also unfolds over several months before ovulation, which is why CoQ10 is usually planned for rather than added at the last minute.

Zita West Kaneka Ubiquinol provides 100mg of ubiquinol per capsule, with a typical two-capsule daily serving providing 200mg. Some people may be advised to take a different amount by their fertility clinic or healthcare professional, but higher intakes should only be followed under supervision. Because CoQ10 is fat-soluble, it is commonly taken with a meal containing fat to support absorption.

For the full breakdown of dosage considerations, see our CoQ10 dosage for fertility guide. For a detailed look at when to begin, see when to start CoQ10 before conception or IVF. To view the product referenced above, see Zita West Kaneka Ubiquinol CoQ10.

How CoQ10 fits into a fertility supplement routine

CoQ10 is usually considered as one part of a wider fertility supplement routine, rather than as a standalone solution. Depending on your circumstances, a preconception plan may also include folate, vitamin D, omega 3, antioxidants, prenatal nutrients or male fertility support. The right combination depends on your age, fertility history, diet, treatment plans and whether one or both partners are preparing for conception.

If you are unsure where CoQ10 fits, Zita West offers stage-specific fertility supplement collections for women, men and those preparing for IVF, as well as free product consultations.

Who may benefit from discussing CoQ10 with a fertility specialist?

Women preparing for IVF or ICSI
Women concerned about egg quality
Women with diminished ovarian reserve
Men with sperm motility or oxidative stress concerns
Couples trying to optimise preconception nutrition
Couples over 35 preparing for conception
Anyone taking medication or undergoing fertility treatment

CoQ10 may not be suitable for everyone. Speak to your GP, fertility clinic or healthcare professional before starting supplements, especially if you are taking medication, undergoing fertility treatment, pregnant, breastfeeding or managing a medical condition.

Not sure whether CoQ10 is right for you? Book a free product consultation with our experts.

Zita West Kaneka Ubiquinol CoQ10 for fertility support

Zita West Kaneka Ubiquinol CoQ10, a premium ubiquinol supplement for egg and sperm quality

Zita West Kaneka Ubiquinol CoQ10 is a fertility-focused CoQ10 supplement for women and men preparing for conception. It uses Kaneka Ubiquinol, the active ubiquinol form of CoQ10, and is designed to support mitochondrial energy and antioxidant protection relevant to egg quality and sperm health. Each capsule provides 100mg of Kaneka Ubiquinol, with a typical two-capsule daily serving providing 200mg. It has been developed through Zita West's fertility expertise, is made in the UK and is third-party tested.

Use according to product directions, or seek personalised guidance from a healthcare professional. View the product here.

Complete your fertility stack

Kaneka Ubiquinol is designed to support mitochondrial energy and antioxidant protection relevant to egg and sperm quality. It works best alongside a wider supplement routine built around your stage of trying. One complementary addition worth knowing about:

Zita West Vital DHA

Kaneka Ubiquinol does not contain omega 3. Vital DHA delivers molecularly distilled DHA and EPA, one of the most consistently recommended additions for egg quality and reproductive health. A natural pairing for anyone taking CoQ10.

Shop Vital DHA

Related CoQ10 fertility guides

Explore the related Zita West guides below for more detail on dosage, timing, forms of CoQ10, Kaneka Ubiquinol research, male fertility and pregnancy safety.

Frequently asked questions

Is CoQ10 good for fertility?

CoQ10 may support fertility by helping cells produce energy and by protecting against oxidative stress. It is most often discussed in relation to egg quality, sperm motility and IVF preparation. It is not a fertility treatment and cannot guarantee pregnancy.

Does CoQ10 improve egg quality?

CoQ10 is studied for its role in mitochondrial energy and antioxidant protection, both relevant to egg development. Some research in assisted reproduction points to potential benefits for ovarian response and clinical pregnancy rate, though evidence for live birth outcomes is less certain.

What is the best form of CoQ10 for fertility?

CoQ10 exists as ubiquinone and ubiquinol. Ubiquinol is the reduced, active antioxidant form and is often chosen in fertility supplements because it does not need to be converted before it works. Zita West uses Kaneka Ubiquinol, a branded form of ubiquinol, in its fertility-focused CoQ10 supplement.

Is Kaneka Ubiquinol better than standard CoQ10?

This depends on individual needs. Kaneka Ubiquinol is a branded form of ubiquinol, while many standard CoQ10 supplements use ubiquinone. Ubiquinol is already in the reduced, active form, so it is often chosen where absorption and age-related conversion are considerations — but standard CoQ10 may still suit some people depending on dose and formulation.

Does CoQ10 help sperm health?

Research suggests CoQ10 may support semen parameters, particularly sperm motility. This may be because sperm need high levels of energy to move effectively, and CoQ10 plays a role in mitochondrial energy production.

How much CoQ10 should I take for fertility?

This depends on individual circumstances and healthcare advice. Zita West Kaneka Ubiquinol provides 100mg of ubiquinol per capsule, with a typical two-capsule daily serving providing 200mg. See our CoQ10 dosage for fertility guide for a fuller breakdown.

How long does CoQ10 take to work for fertility?

Many people consider taking CoQ10 for around three months before trying to conceive or before fertility treatment, because egg and sperm development take time. Personal advice should come from a GP, fertility clinic or qualified healthcare professional. See our timing guide for more detail.

Is ubiquinol better than ubiquinone for fertility?

Ubiquinol is the reduced, active antioxidant form of CoQ10, while ubiquinone is the oxidised form. Ubiquinol is often chosen in fertility supplements because it is a highly bioavailable form, though the best option depends on the product, dose and individual needs.

Should men take CoQ10 when trying to conceive?

Yes, CoQ10 is commonly included in male fertility supplement plans because of its role in energy production and antioxidant protection. Research has explored its effects on sperm motility, concentration, morphology and oxidative stress. Read more in our CoQ10 and male fertility guide.

Can I take CoQ10 during IVF?

Some people take CoQ10 as part of IVF preparation, particularly when focusing on egg quality, ovarian response or sperm health. Always check with your fertility clinic before taking supplements during IVF, especially if you are following a specific treatment protocol.

Can I take CoQ10 with prenatal vitamins?

CoQ10 is often taken alongside preconception or prenatal supplements, but combinations should be checked carefully to avoid unnecessary overlap or unsuitable ingredients. Speak to a healthcare professional if you are unsure.

Is CoQ10 safe when trying to conceive?

CoQ10 is generally considered well tolerated in studies, though it may not be appropriate for everyone. Seek medical advice if you are taking medication, have a medical condition, are undergoing fertility treatment, or are pregnant or breastfeeding.

Is CoQ10 safe during pregnancy?

There is not enough evidence to recommend routine CoQ10 use during pregnancy unless advised by a healthcare professional. See our dedicated guide, is CoQ10 safe in pregnancy or only during conception?, for a fuller explanation.

When should I stop taking CoQ10?

This depends on your personal circumstances and fertility plan. Some people take it only during the preconception phase, while others continue under professional guidance. This can also depend on whether you become pregnant — see is CoQ10 safe in pregnancy or only during conception?. Ask your GP, fertility clinic or healthcare professional what is appropriate for you.

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